colony formation — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T22089	HPI 1		Hedgehog/Smoothened
	HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4, and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced a...		Hedgehog/Smoothened
T10723	CDC25B-IN-1	ethyl 3-[(3-methoxynaphthalen-1-yl)amino]benzoate	Phosphatase
	CDC25B-IN-1 is an inhibitor of CDC25B with a Ki of 8.5 μM. CDC25B-IN-1 increases the G2/M phase by inhibiting cell proliferation and colony formation.		Phosphatase
T2011	RKI1313	RKI 1313,RKI-1313	ROCK
	RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasion.		ROCK
TN2269	Tetramethylcurcumin		Apoptosis , STAT
	Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it also inhibits colony formation in soft agar, cell invasion, and e...		Apoptosis , STAT
T61722	ZDLD20		Apoptosis
	ZDLD20 is an orally active and selective CDK4 inhibitor, a β-carboline analog with anti-HCT116 and anticancer activity that inhibits colony formation, inhibits invasion and migration, induces apoptosis, and prevents the ...		Apoptosis
T60197	UNC 1025		Others
	UNC1062 is a highly selective tyrosine kinase inhibitor that specifically targets MERTK. This compound effectively suppresses MERTK-mediated downstream signaling, induces apoptosis in cell cultures, reduces colony format...		Others
T37518	Diphenyl disulfide	Phenyl disulfide	Apoptosis , BCL , Endogenous Metabolite
	Diphenyl disulfide (Phenyl disulfide) shows anticancer activity in breast cancer cell lines.Diphenyl disulfide induces and enhances apoptosis in breast cancer cells through Bax protein hydrolysis activation and concomita...		Apoptosis , BCL , Endogenous Metabolite
T77677	12R-LOX-IN-2		Lipoxygenase
	12R-LOX-IN-2 is an inhibitor of 12R-lipoxygenase (12R-LOX).12R-LOX-IN-2 inhibits imiquimod (IMQ)-induced hyperproliferation of psoriatic keratinocytes and inhibits colony formation.12R-LOX-IN-2 also decreases the protein...		Lipoxygenase
T26358	(-)-Agelastatin A
	(-)-Agelastatin A inhibits osteopontin-mediated adhesion, invasion, and colony formation.
T23726	WB-308	WB308
	WB-308 is an EGFR inhibitor that acts by decreasing NSCLC cell proliferation and colony formation and causing G2/M arrest and apoptosis.
T28848	SR31527	SR-31527,SR31527 chloride,SR 31527	Kinesin
	SR31527 (SR31527 chloride) is a potent KIFC1 inhibitor with an IC50 of 6.6 µM against KIFC1. SR31527 chloride has a moderate inhibitory effect on cell viability and colony formation.		Kinesin
T11691	IV-23		Others
	IV-23, a potent inhibitor of cell growth both in vitro and in vivo, effectively reduces colony formation, arrests the cell cycle at the M phase, and induces apoptosis in esophageal squamous cell carcinoma through Noxa-me...		Others
T24411	Y08060	Y 08060,Y-08060
	Y08060 is an effective and selective BET Inhibitor for the Treatment of Prostate Cancer. Y08060 effectively suppresses cell growth, colony formation, and expression of androgen receptor (AR), AR regulated genes, and MYC ...
T79289	Antiproliferative agent-27		Apoptosis
	Antiproliferative Agent-27 (Compound 11) is a notable antiproliferative agent that markedly diminishes tumor cell colony formation and induces apoptosis, demonstrating potential for utilization in cancer research [1].		Apoptosis
T60672	GSD-11
	GSD-11 inhibits the Akt/mTOR signaling pathway. GSD-11 inhibits the PANC-1 cells migration and colony formation. GSD-11 is a potent and selective anti-austerity agent that has the potential for the pancreatic cancer rese...
T74919	QA-68
	QA-68 (QA-68-ZU81), a potent bromodomain-containing protein 9 (BRD9) degrader, effectively inhibits cell cycle progression and cell colony formation. Demonstrating antiproliferative activity, this compound is particularl...
T78768	HDAC6-IN-16		HDAC
	HDAC6-IN-16 (compound 5c), a quinazolin-4(3H)-one-based inhibitor of histone deacetylase 6 (HDAC6), demonstrates an anticancer effect by inhibiting colony formation, arresting the cell cycle at the G2 phase, and inducing...		HDAC
T79434	Antitumor agent-103		Apoptosis
	Antitumor Agent-103 (compound 24l) induces apoptosis and possesses antiproliferative and anti-colony formation properties. This compound halts the cell cycle at the G0/G1 phase, augments nitric oxide (NO) production, and...		Apoptosis
T78746	Mtb-IN-3
	Mtb-IN-3 (compound 10c), a selective and potent Mycobacterium tuberculosis (Mtb) inhibitor, exhibits strong antimycobacterial activity in vitro without inducing cytotoxic effects and inhibits colony formation in the sple...
T69205	GGTI-2166
	GGTI-2166 is a geranylgeranyl transferase I inhibitor. GGTI-2166 inhibit the pOC formation induced by RANKL or TNF-alpha in cultures of both mouse marrow-derived macrophage-colony-stimulating factor (M-CSF) dependent mo...